Palladium-catalyzed diastereoselective cyclization of the allylic precursors. A concise synthetic route to 3-azabicyclo[3.3.0]octane and hydroisoindole skeletons
Yg. Suh et al., Palladium-catalyzed diastereoselective cyclization of the allylic precursors. A concise synthetic route to 3-azabicyclo[3.3.0]octane and hydroisoindole skeletons, SYN COMMUN, 30(16), 2000, pp. 3053-3060
A useful variant of palladium-catalyzed 1,2-diastereoselective cyclization
of the allylic precursors based on the steric nature of the anion stabilizi
ng groups has been developed. The 1,1,2-trisubstituted cycloalkane products
have also been efficiently transformed into the azabicyclic systems.