Caenorhabditis elegans senses protons through amphid chemosensory neurons:proton signals elicit avoidance behavior

Citation
Y. Sambongi et al., Caenorhabditis elegans senses protons through amphid chemosensory neurons:proton signals elicit avoidance behavior, NEUROREPORT, 11(10), 2000, pp. 2229-2232
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
11
Issue
10
Year of publication
2000
Pages
2229 - 2232
Database
ISI
SICI code
0959-4965(20000714)11:10<2229:CESPTA>2.0.ZU;2-D
Abstract
Acidic pH is known to cause pain sensation through nociceptive neurons as w ell as taste transduction in mammals. Caenorhabditis elegans avoids an acid ic environment (pH lower than similar to 4.0) formed by organic or inorgani c acids. This avoidance behavior was dependent on multiple amphid chemosens ory neurons, and inhibited by a mutation of capsaicin receptor homologue, a nd by the addition of amiloride and ruthenium red (inhibitors of proton-gat ed Na+ channels and capsaicin receptors, respectively). These results indic ate that C. elegans recognizes protons as a nociceptive stimulus, through m ultiple neurons, which elicits avoidance behavior. It is of special interes t that a system similar to that of mammalian signal transduction is respons ible for this nematode's acid avoidance. NeuroReport 11:2229-2232 (C) 2000 Lippincott Williams & Wilkins.