The flowers of Albizzia julibrissin are used as a sedative in oriental trad
itional medicine. The phytochemical study of this plant allowed the isolati
on of two flavonol glycosides, quercitrin (1) and isoquercitrin (2). The se
dative activity of these compounds was evaluated, and both compounds 1 and
2 increased pentobarbital-induced sleeping time in dose-dependent manner in
mice. These results support the use of the flowers of this plant as a seda
tive agent. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.