Autocrine motility factor receptor expression associates with tumor progression in thymoma

Citation
Y. Ohta et al., Autocrine motility factor receptor expression associates with tumor progression in thymoma, INT J ONCOL, 17(2), 2000, pp. 259-264
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN journal
1019-6439 → ACNP
Volume
17
Issue
2
Year of publication
2000
Pages
259 - 264
Database
ISI
SICI code
1019-6439(200008)17:2<259:AMFREA>2.0.ZU;2-C
Abstract
We assessed the autocrine motility factor receptor (AMFR/gp78) expression i n thymoma. AMFR/gp78 antigen was identified in tumor cells in 16 out of 51 (31.4%) thymomas. The AMFR/gp78 expression was closely associated with the stage (I/II vs. III/IV, p<0.0001), pathological subtypes (epithelial vs. ot her types, p=0.0214), and enhanced expression of ex-smooth-muscle actin wit hin stroma (p<0.0001). The outcome of the patients with AMFR/gp78 expressio n was significantly worse than for those without it (p<0.01). All initial t umors with recurrence expressed AMFR/gp78. The AMFR/gp78 appears to be invo lved in tumor progression in thymoma.