Relationship between hypertensive left ventricular hypertrophy and levels of endothelin and nitric oxide

Citation
Ly. Hua et al., Relationship between hypertensive left ventricular hypertrophy and levels of endothelin and nitric oxide, HYPERTENS R, 23(4), 2000, pp. 377-380
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
Hypertension research
ISSN journal
0916-9636 → ACNP
Volume
23
Issue
4
Year of publication
2000
Pages
377 - 380
Database
ISI
SICI code
Abstract
To investigate the relationship between hypertensive left ventricular hyper trophy(LVH) and levels of endothelin (ET) and nitric oxide (NO), and to pro vide an experimental basis for prevention and treatment of hypertensive LVH , Fifty eight hypertensive patients and 14 healthy controls were studied. A ll patients were examined by echocardiography. Left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated using Devereux RE fo rmula. Hypertensive patients were divided into a LVH (+) group (n = 21) and a LVH (-) group (n = 37), and the levels of endothelin and nitric oxide in the peripheral venous blood were measured. The mean ET level was significa ntly higher in the LVH (+) group than in LVH (-) group (p < 0.05), but the NO level was significantly lower in the LVH (+) group. The ET/NO ratio was significantly higher in the LVH (+) group than in LVH (-) group (p < 0.01). For the stepwise multiple regression analysis, the LVMI of hypertensive pa tients served as a dependent variable, and age, sex, BMI, MAP, ET, NO, and ET/NO served as independent variables, Only MAP, ET, and NO were found to h ave significant correlation to hypertensive LVH. ET had a significant posit ive correlation, and NO a significant negative relation to LVMI, but ET/NO showed no correlation to hypertensive LVH, ET and NO are involved in hypert ensive LVH; the independent action of ET and NO in the pathogenesis of hype rtensive LVH may weaken the relation between ET/NO and hypertensive LVH.