Ly. Hua et al., Relationship between hypertensive left ventricular hypertrophy and levels of endothelin and nitric oxide, HYPERTENS R, 23(4), 2000, pp. 377-380
To investigate the relationship between hypertensive left ventricular hyper
trophy(LVH) and levels of endothelin (ET) and nitric oxide (NO), and to pro
vide an experimental basis for prevention and treatment of hypertensive LVH
, Fifty eight hypertensive patients and 14 healthy controls were studied. A
ll patients were examined by echocardiography. Left ventricular mass (LVM)
and left ventricular mass index (LVMI) were calculated using Devereux RE fo
rmula. Hypertensive patients were divided into a LVH (+) group (n = 21) and
a LVH (-) group (n = 37), and the levels of endothelin and nitric oxide in
the peripheral venous blood were measured. The mean ET level was significa
ntly higher in the LVH (+) group than in LVH (-) group (p < 0.05), but the
NO level was significantly lower in the LVH (+) group. The ET/NO ratio was
significantly higher in the LVH (+) group than in LVH (-) group (p < 0.01).
For the stepwise multiple regression analysis, the LVMI of hypertensive pa
tients served as a dependent variable, and age, sex, BMI, MAP, ET, NO, and
ET/NO served as independent variables, Only MAP, ET, and NO were found to h
ave significant correlation to hypertensive LVH. ET had a significant posit
ive correlation, and NO a significant negative relation to LVMI, but ET/NO
showed no correlation to hypertensive LVH, ET and NO are involved in hypert
ensive LVH; the independent action of ET and NO in the pathogenesis of hype
rtensive LVH may weaken the relation between ET/NO and hypertensive LVH.