Synthesis of 1,2,4-triazolo[3,2-d][1,5]benzoxazepine compounds

Citation
Xj. Liu et al., Synthesis of 1,2,4-triazolo[3,2-d][1,5]benzoxazepine compounds, CHEM J CH U, 21(7), 2000, pp. 1052-1055
Citations number
9
Language
CHINESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN journal
0251-0790 → ACNP
Volume
21
Issue
7
Year of publication
2000
Pages
1052 - 1055
Database
ISI
SICI code
0251-0790(200007)21:7<1052:SO1C>2.0.ZU;2-4
Abstract
Azocarbenium ions 3, prepared in situ from 4-chromanone arylhydrazones 1, c ycloadd readily to the triple bond of nitriles forming 3-spiro substituted 1,2,4-triazolium salts 4. The initial cycloadducts 4 cannot be isolated but undergo consecutive reactions, e.g. [1,2]-shifts and ensuing ring enlargem ent to provide 1, 2, 4-triazolo [3, 2-d] [1, 5] benzoxazepine compounds 5a- 5k, a kind of novel tricyclic heterocycles.