Apolipoprotein-E and white matter hyperintensities in late-life depression

Citation
H. Lavretsky et al., Apolipoprotein-E and white matter hyperintensities in late-life depression, AM J GER PS, 8(3), 2000, pp. 257-261
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry
Journal title
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
ISSN journal
1064-7481 → ACNP
Volume
8
Issue
3
Year of publication
2000
Pages
257 - 261
Database
ISI
SICI code
1064-7481(200022)8:3<257:AAWMHI>2.0.ZU;2-D
Abstract
The authors conducted a follow-up study of 16 patients with late-life depre ssion approximately 6 years after their initial assessment to evaluate the relationships between apolipoprotein-E (APO-E) status and white-matter hype rintensities (WMH). Ten patients had WMH at baseline, and four patients dem onstrated cm increase in WMH size over time. Three of four patients with th e APO-E epsilon 4 allele demonstrated an increase in WMH over time, and onl y I of 12 patients Without an epsilon 4 allele had an increase in WMH. Thre e of four patients with APO-E epsilon 4 allele developed a chronic course o f major depression at follow-up. Patients with APO-E epsilon 4 had a higher number of depressive episodes and lower age at onset. APO-E may be a risk factor for cerebrovascular disease associated with late-life depression and may affect the clinical characteristics and disease course of depression.