Abolition and reversal of strain differences in behavioral responses to drugs of abuse after a brief experience

Citation
S. Cabib et al., Abolition and reversal of strain differences in behavioral responses to drugs of abuse after a brief experience, SCIENCE, 289(5478), 2000, pp. 463-465
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary,Multidisciplinary,Multidisciplinary
Journal title
SCIENCE
ISSN journal
0036-8075 → ACNP
Volume
289
Issue
5478
Year of publication
2000
Pages
463 - 465
Database
ISI
SICI code
0036-8075(20000721)289:5478<463:AAROSD>2.0.ZU;2-E
Abstract
Inbred strains of mice are Largely used to identify the genetic basis of no rmal and pathological behaviors. This report demonstrates that a moderate p eriod of food shortage, an ecologically common experience, can reverse or a bolish strain differences in behavioral responses to the abused psychostimu lant amphetamine. The period of food shortage occurred when the animals wer e mature and was terminated before the administration of amphetamine. Strai n differences in behavior appear highly dependent on environmental experien ces. Consequently, to identify biological determinants of behavior, an inte grated approach considering the interaction between environmental and genet ic factors needs to be used.