The aldo-keto reductase superfamily catalyzes the reduction of a broad rang
e of aldehydes and ketones to their corresponding alcohols. Here we report
the cloning of the mouse aldehyde reductase cDNA and its embryonic pattern
of expression. From stages E7.5 to E13.5 the gene encoding for this enzyme
is expressed at high levels in several tissues, including the neural ectode
rm, gut endoderm, somites, branchial arches, otic vesicles, limb buds, and
tail bud. In adult mice aldehyde reductase was expressed in all tissues exa
mined. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.