Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion

Citation
L. Tian et al., Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion, J CELL BIOL, 150(1), 2000, pp. 243-252
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
JOURNAL OF CELL BIOLOGY
ISSN journal
0021-9525 → ACNP
Volume
150
Issue
1
Year of publication
2000
Pages
243 - 252
Database
ISI
SICI code
0021-9525(20000710)150:1<243:IAMIDO>2.0.ZU;2-J
Abstract
Intercellular adhesion molecule-5 (ICAM-5) is a dendritically polarized mem brane glycoprotein in telencephalic neurons, which shows heterophilic bindi ng to leukocyte beta(2)-integrins. Here, we show that the human ICAM-5 prot ein interacts in a hemophilic manner through the binding of the immunoglobu lin domain 1 to domains 4-5. Surface coated ICAM-5-Fc promoted dendritic ou tgrowth and arborization of ICAM-5-expressing hippocampal neurons. During d endritogenesis in developing rat brain, ICAM-5 was in monomer form, whereas in mature neurons it migrated as a high molecular weight complex. The find ings indicate that its homophilic binding activity was regulated by nonmono mer/monomer transition. Thus, ICAM-5 displays two types of adhesion activit y, homophilic binding between neurons and heterophilic binding between neur ons and leukocytes.