Kit signal transduction

Citation
Ml. Taylor et Dd. Metcalfe, Kit signal transduction, HEMAT ONCOL, 14(3), 2000, pp. 517
Citations number
111
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
ISSN journal
0889-8588 → ACNP
Volume
14
Issue
3
Year of publication
2000
Database
ISI
SICI code
0889-8588(200006)14:3<517:KST>2.0.ZU;2-F
Abstract
The proto-oncogene c-kit was first identified as the cellular homologue of the oncogene v-kit, isolated from the retrovirus HZ-4-feline sarcoma, which causes multicentric fibrosarcomas.(2) This proto-oncogene encodes a transm embrane type III tyrosine kinase receptor (molecular weight 145-160 kd) whi ch displays extensive homology with other members of this tyrosine kinase r eceptor family, such as platelet-derived growth factor (PDGF) and colony-st imulating factor-1 (CSF-1 or c-fms).(104) In humans, the c-kit gene maps to chromosome 4 (4q11 12), which is in close proximity to the PDGF receptor a nd to the epidermal growth factor (EGF) receptor. Kit protein has also been shown to be identical to the product of the murine dominant white-spotting W locus on chromosome 5 and as such is integral to the development of mast cells and hematopoiesis.(18) Alternative splicing results in two naturally occurring isoforms of kit tha t contain (kit A) or lack (kit) four amino acids (Gly Asn Asn Lys) at codon 510 just outside the transmembrane domain.(85) The biologic significance o f these isoforms, however, remains unclear. These two isoforms have been re ported to coexist in normal tissues at a ratio of 1:5 (kit A:kit). This rat io varies considerably in patients with acute myelogenous leukemia. Kit is expressed on mast cells, hematopoietic stem cells, melanocytes, game tocytes, intraepithelial lymphocytes, and interstitial cells of cajal.