Cardioactive peptides isolated from the brain of a Japanese octopus, Octopus minor

Citation
E. Iwakoshi et al., Cardioactive peptides isolated from the brain of a Japanese octopus, Octopus minor, PEPTIDES, 21(5), 2000, pp. 623-630
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
0196-9781 → ACNP
Volume
21
Issue
5
Year of publication
2000
Pages
623 - 630
Database
ISI
SICI code
0196-9781(200005)21:5<623:CPIFTB>2.0.ZU;2-G
Abstract
Octopus cardioactive peptides (Ocp-1: Gly-D-Phe-Gly-Asp, and Ocp-3: Gly-Ser -Trp-Asp) were isolated from brain extracts of the octopus, Ocropus minor, using the isolated systemic heart as a bioassay. These peptides showed both positive chronotropic and inotropic effects on the heart. The stereoisomer s at position 2 were also isolated, but their activities were only 1/10(3)- 1/10(4) those of the corresponding isomers. The presence of the peptides in the systemic heart was confirmed by time-of-flight mass spectrometry (MS) and tandem MS analysis. The results suggested that Ocp-1 and Ocp-3 might be involved in excitatory control of the octopus cardiovascular system as neu ropeptides and/or neurohormones. (C) 2000 Elsevier Science Inc. All rights reserved.