The fib locus in Streptococcus pneumoniae is required for peptidoglycan crosslinking and PBP-mediated beta-lactam resistance

Citation
B. Weber et al., The fib locus in Streptococcus pneumoniae is required for peptidoglycan crosslinking and PBP-mediated beta-lactam resistance, FEMS MICROB, 188(1), 2000, pp. 81-85
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
FEMS MICROBIOLOGY LETTERS
ISSN journal
0378-1097 → ACNP
Volume
188
Issue
1
Year of publication
2000
Pages
81 - 85
Database
ISI
SICI code
0378-1097(20000701)188:1<81:TFLISP>2.0.ZU;2-D
Abstract
Penicillin resistance in pneumococci is mediated by modified penicillin-bin ding proteins (PBPs) that have decreased affinity to beta-lactams In high-l evel penicillin-resistant transformants of the laboratory strain Streptococ cus pneumoniae R6 containing various combinations of low-affinity PBPs, dis ruption of the fib locus results in a collapse of PBP-mediated resistance. In addition, crosslinked muropeptides are highly reduced. The fib operon co nsists of two genes, fibA and fibB, homologous to Staphylococcus aureus fem A/B which are also required for expression of methicillin resistance in thi s organism. FibA and FibB belong to a family of proteins of Gram-positive b acteria involved in the formation of interpeptide bridges, thus representin g interesting new targets for antimicrobial compounds for this group of pat hogens. (C) 2000 Federation of European Microbiological Societies. Publishe d by Elsevier Science B.V. All rights reserved.