Electroanalysis of glucose in transcutaneously extracted samples

Citation
Mj. Tierney et al., Electroanalysis of glucose in transcutaneously extracted samples, ELECTROANAL, 12(9), 2000, pp. 666-671
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ELECTROANALYSIS
ISSN journal
1040-0397 → ACNP
Volume
12
Issue
9
Year of publication
2000
Pages
666 - 671
Database
ISI
SICI code
1040-0397(200005)12:9<666:EOGITE>2.0.ZU;2-V
Abstract
Glucose can be extracted through intact skin by electroosmosis upon applica tion of a low-level electrical current. The amount of glucose extracted has been shown previously to correlate with blood glucose level. An amperometr ic, GOx-based biosensor was used to measure the amount of glucose in sample s extracted from a nondiabetic volunteer every twenty minutes for five hour s. The blank-subtracted current output from this sensor accurately tracked blood glucose changes and correlated with the capillary blood glucose value s (average, > 0.93) and a time lag of twenty minutes. This proof-of-feasibi lity is a prerequisite to the development of an integrated, wearable glucos e monitor for diabetics combining both biosensor and iontophoresis function s.