A large-scale model of the cerebellar cortex using PGENESIS

Citation
Fw. Howell et al., A large-scale model of the cerebellar cortex using PGENESIS, NEUROCOMPUT, 32, 2000, pp. 1041-1046
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
AI Robotics and Automatic Control
Journal title
NEUROCOMPUTING
ISSN journal
0925-2312 → ACNP
Volume
32
Year of publication
2000
Pages
1041 - 1046
Database
ISI
SICI code
0925-2312(200006)32:<1041:ALMOTC>2.0.ZU;2-M
Abstract
In an investigation into the transformation of mossy fiber input to Purkinj e cell output in the cerebellar cortex, we have developed a network model i ncluding a sophisticated compartmental model of the Purkinje cell. Analysis and simulations demonstrated the need to include a large number of paralle l fibers (244000) to obtain realistic Purkinje cell firing patterns for ran dom mossy fiber input. Using smaller numbers of parallel fiber inputs resul ted in unrealistic Purkinje cell spiking characterized by spontaneous dendr itic calcium spikes. Because the scale required is beyond workstation capab ilites, we used a 128-processor Gray T3E running PGENESIS. This size networ k could produce realistic spiking patterns provided the stellate cell inhib ition was tuned carefully. (C) 2000 Elsevier Science B.V. All rights reserv ed.