Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation

Citation
Jc. Yoon et al., Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation, MOL CELL B, 20(14), 2000, pp. 5343-5349
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR AND CELLULAR BIOLOGY
ISSN journal
0270-7306 → ACNP
Volume
20
Issue
14
Year of publication
2000
Pages
5343 - 5349
Database
ISI
SICI code
0270-7306(200007)20:14<5343:PPRGTG>2.0.ZU;2-Q
Abstract
The nuclear receptor peroxisome proliferator-activated receptor gamma regul ates adipose differentiation and systemic insulin signaling via ligand-depe ndent transcriptional activation of target genes. However, the identities o f the biologically relevant target genes are largely unknown. Here we descr ibe the isolation and characterization of a novel target gene induced by PP AR gamma ligands, termed PGAR (for PPAR gamma angiopoietin related), which encodes a novel member of the angiopoietin family of secreted proteins. The transcriptional induction of PGAR follows a rapid time course typical of i mmediate-early genes and occurs in the absence of protein synthesis. The ex pression of PGAR is predominantly localized to adipose tissues and placenta and is consistently elevated in genetic models of obesity. Hormone-depende nt adipocyte differentiation coincides with a dramatic early induction of t he PGAR transcript. Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data s uggest a possible role for PGAR in the regulation of systemic lipid metabol ism or glucose homeostasis.