Patients' understanding of their own disease and survival potential in patients with metastatic breast cancer

Citation
H. Okamura et al., Patients' understanding of their own disease and survival potential in patients with metastatic breast cancer, BREAST CANC, 61(2), 2000, pp. 145-150
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BREAST CANCER RESEARCH AND TREATMENT
ISSN journal
0167-6806 → ACNP
Volume
61
Issue
2
Year of publication
2000
Pages
145 - 150
Database
ISI
SICI code
0167-6806(200005)61:2<145:PUOTOD>2.0.ZU;2-S
Abstract
Purpose: To investigate the effect of understanding their own disease by pa tients with metastatic breast cancer on their survival potential after bein g informed by their physician. Patients and methods: Two hundred and fourteen women with metastatic breast cancer who participated in a multi-institutional, randomized phase III tri al (Japan Clinical Oncology Group (JCOG) Study 8808) were asked whether the y understood their own disease after being given information about the clin ical trial. They were classified into two groups on the basis of whether th ey understood or not. We estimated their survival after the time of registr ation and derived relative hazard ratios from Cox's proportional hazards mo del. Results: There were 190 patients in the 'better understanding' group and 24 in the 'poor understanding' group. Median survival times after registratio n were 28.3 and 16.1 months, respectively. The 'better understanding' group showed a significant difference from the 'poor understanding' group (p = 0 .016). In multivariate regression analysis, patients who did not understand still showed poorer survival than those who understood (hazard ratio = 2.0 9; 95% confidence interval (CI) 1.16-3.78; p = 0.014). Conclusion: These results support the supposition that patients' understand ing of information about their disease may influence their survival. Thus, it is important to evaluate patients' recognition about information even af ter obtaining their consent. However, further investigation is needed to cl arify the exact nature of this relationship.