Protective mechanisms against the intestinal nematode Strongyloides venezuelensis in Schistosoma japonicum-infected mice

Citation
H. Maruyama et al., Protective mechanisms against the intestinal nematode Strongyloides venezuelensis in Schistosoma japonicum-infected mice, PARASITE IM, 22(6), 2000, pp. 279-286
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
PARASITE IMMUNOLOGY
ISSN journal
0141-9838 → ACNP
Volume
22
Issue
6
Year of publication
2000
Pages
279 - 286
Database
ISI
SICI code
0141-9838(200006)22:6<279:PMATIN>2.0.ZU;2-W
Abstract
Mice infected with Schistosoma japonicum were resistant to the intestinal n ematode, Strongyloides venezuelensis. The numbers of adult S. venezuelensis recovered from mice were significantly decreased when infections were give n from 6 weeks after S. japonicum infection. Larval recovery from the lungs showed that significant numbers of subcutaneously inoculated S. venezuelen sis larvae were eliminated by 3 days in S. japonicum-infected mice (P < 0.0 001), while histology revealed that this was associated with massive eosino philic infiltration in the lungs. In addition, adult S. venezuelensis worms implanted in the duodenum of S. japonicum-infected mice could not establis h in the intestine. This failure was associated with mucosal mastocytosis. Activation of eosinophils and intestinal mast cells was con elated with ele vated expression of mRNA for interleukin (IL)-3, IL-4, and IL-5 in S. japon icum-infected mice. Sera from S, japonicum-infected mice recognized S. vene zuelensis larva antigens as strongly as those from S. venezuelensis-infecte d mice, although transfer of sera from S. japonicum-infected mice to normal recipient mice did not protect them from S. venezuelensis challenge infect ion. It was concluded that the mechanisms for larval killing and adult worm expulsion of S. venezuelensis in S. japonicum-infected mice were identical to those seen in infections with S. venezuelensis only.