Enhanced GAP-43 gene expression in cortical dysplasia

Citation
H. Yamanouchi et al., Enhanced GAP-43 gene expression in cortical dysplasia, NEUROREPORT, 11(9), 2000, pp. 1815-1819
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
11
Issue
9
Year of publication
2000
Pages
1815 - 1819
Database
ISI
SICI code
0959-4965(20000626)11:9<1815:EGGEIC>2.0.ZU;2-Q
Abstract
Growth-associated protein GAP-43, a phosphoprotein enriched at presynaptic nerve terminals, is thought to be involved in axonal outgrowth and plastici ty in synaptic connections. To explore the synaptic remodeling under the ep ileptic conditions, we examined GAP-43 expression in brain specimens surgic ally resected as epileptogenic foci from 17 patients with cortical dysplasi a. In situ hybridization with GAP-43 antisense riboprobe showed significant ly increased signals in the dysplastic large neurons of cortical dysplasia. Specific distribution with increased immunoreactivity for GAP-43 was not s hown in the dysplastic cortex. These results suggest that GAP-43 gene expre ssion is over-expressed in the dysplastic large neurons, reflecting activat ed synaptic remodeling in the epileptic condition of cortical dysplasia, al though the precise site of accelerated synaptic rearrangement remains unkno wn. NeuroReport 11:1815-1819 (C) 2000 Lippincott Williams & Wilkins.