USE OF SILICON AND GAAS PIXEL DETECTORS FOR DIGITAL AUTORADIOGRAPHY

Citation
Sr. Amendolia et al., USE OF SILICON AND GAAS PIXEL DETECTORS FOR DIGITAL AUTORADIOGRAPHY, IEEE transactions on nuclear science, 44(3), 1997, pp. 929-933
Citations number
3
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Nuclear Sciences & Tecnology","Engineering, Eletrical & Electronic
ISSN journal
0018-9499
Volume
44
Issue
3
Year of publication
1997
Part
1
Pages
929 - 933
Database
ISI
SICI code
0018-9499(1997)44:3<929:UOSAGP>2.0.ZU;2-S
Abstract
Solid state detectors made of Si (4.8x8 mm(2)) and GaAs (6.4x8 mm(2)) pixel matrices bump-bonded to the Omega2 and Omega3 electronic read-ou t systems, developed at CERN for H.E.P. experiments, have been used to obtain autoradiographic images of clusters of human epithelial cells and DNA fragments separated via electrophoresis, both labeled with P-3 2. The system has shown a good minimum detectable activity per unit ar ea of 2. 10(-4) cps mm(-2), and has proved linear for count rate in th e range 0.2-20 cpa, typical of autoradiography. The pixel dimensions a re 75x500 mu m(2) (Si-Omega2) and 50x500 mu m(2)(GaAs-Omega3), respect ively. We are able to clearly localize clusters of cells which have in corporated the radioactive tracer and DNA fragments on an electrophore tic gel on paper (blots).