M. Kato et al., Cowden's disease diagnosed through mucocutaneous lesions and gastrointestinal polyposis with recurrent hematochezia, unrevealed by initial diagnosis, INTERN MED, 39(7), 2000, pp. 559-563
A 51-year-old man was admitted to our hospital because of hematochezia and
painful keratotic plaques involving both hands. He had gastrointestinal pol
yposis, and a history of liver hemangiomas and thyroid tumor. Numerous papu
les on the face and papillomatosis on the oral mucosa were present. A diagn
osis was made as a typical case of Cowden's disease according to the criter
ia proposed by Salem and Steck (J Am Acad Dermatol 8: 686, 1983), The patie
nt was not correctly diagnosed initially in spite of typical manifestations
of Cowden's disease, mainly due to his concomitant manifestations which oc
curred chronologically.