There is increasing evidence in a number of neurodegenerative diseases that
transition metal-mediated abnormalities play a crucial role in disease pat
hogenesis. In this treatise, we review the role of metal homeostasis as it
pertains to alterations in brain function in neurodegenerative diseases. In
fact, while there is documented evidence for alterations in transition met
al homeostasis, redox-activity and localization, it is also important to re
alize that alterations in specific copper- and iron-containing metalloenzym
es also appear to play a crucial role in the neurodegenerative process.