The role of metals in neurodegenerative diseases

Citation
Lm. Sayre et al., The role of metals in neurodegenerative diseases, CELL MOL B, 46(4), 2000, pp. 731-741
Citations number
75
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR BIOLOGY
ISSN journal
0145-5680 → ACNP
Volume
46
Issue
4
Year of publication
2000
Pages
731 - 741
Database
ISI
SICI code
0145-5680(200006)46:4<731:TROMIN>2.0.ZU;2-M
Abstract
There is increasing evidence in a number of neurodegenerative diseases that transition metal-mediated abnormalities play a crucial role in disease pat hogenesis. In this treatise, we review the role of metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases. In fact, while there is documented evidence for alterations in transition met al homeostasis, redox-activity and localization, it is also important to re alize that alterations in specific copper- and iron-containing metalloenzym es also appear to play a crucial role in the neurodegenerative process.