Distinct B-cell populations are present in hepatic and intestinal Schistosoma mansoni granulomas

Citation
W. Jacobs et al., Distinct B-cell populations are present in hepatic and intestinal Schistosoma mansoni granulomas, ACT GASTR B, 62(2), 1999, pp. 178-181
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
ACTA GASTRO-ENTEROLOGICA BELGICA
ISSN journal
0001-5644 → ACNP
Volume
62
Issue
2
Year of publication
1999
Pages
178 - 181
Database
ISI
SICI code
0001-5644(199904/06)62:2<178:DBPAPI>2.0.ZU;2-M
Abstract
Although it is generally accepted that schistosomal granuloma formation res ults from a T-cell dependent host response towards the parasite egg, attent ion has recently been focused on the involvement of B-cells in the inductio n of schistosome-induced pathology. In this study we investigated the invol vement of two functionally different B-cell populations in the formation of the Schistosoma mansoni granuloma :naive and antigen-stimulated B-cells, I n liver granulomas two distinct B-cell populations were found, namely unsti mulated B-cells at the periphery of the granuloma and antigen-stimulated, s yndecan-1 positive B-cells in the inner part near the deposited egg. Intest inal granulomas differed by their relative lack of unstimulated B-cells at the granuloma periphery, but like hepatic granulomas intestinal granulomas also have syndecan-1 positive B-cells, From our results, we conclude that B -cells are important constituents of the S. mansoni granuloma.