Spontaneously regressed Kaposi's sarcoma and human herpesvirus 8 infectionin a human immunodeficiency virus-negative patient

Citation
Y. Kondo et al., Spontaneously regressed Kaposi's sarcoma and human herpesvirus 8 infectionin a human immunodeficiency virus-negative patient, PATHOL INT, 50(4), 2000, pp. 340-346
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
PATHOLOGY INTERNATIONAL
ISSN journal
1320-5463 → ACNP
Volume
50
Issue
4
Year of publication
2000
Pages
340 - 346
Database
ISI
SICI code
1320-5463(200004)50:4<340:SRKSAH>2.0.ZU;2-O
Abstract
Kaposi's sarcoma occurring in a 78-year-old woman, with the absence of the human immunodeficiency virus infection, was correctly diagnosed by immunohi stochemistry using anti-human herpesvirus 8 (HHV8) antibody (PA1-73N) for t he first time. The patient suffered from chronic respiratory failure and wa s treated with a low dose of steroids for 2.5 years. After her medication d osage was increased for the exacerbation of the respiratory failure, multip le skin tumors in her feet and legs suddenly developed. Histopathologically , skin tumors were suspected as Kaposi's sarcoma at the first biopsy and re active angiomatosis at the second biopsy. Polymerase chain reaction and imm unohistochemistry, however, revealed the presence of HHV8 DNA fragment and positive staining in the majority of spindle cells in the skin tumors. Sero logical examination confirmed the positivity of anti-HHV8 antibodies. HHV8 infection and steroid-induced immunosuppression, as well as environmental f actors played a role in the development of Kaposi's sarcoma in this patient , because she was born in Okinawa, which is a well-known endemic area of Ka posi's sarcoma in Japan. As her general condition improved, the skin lesion s regressed without any specific treatment, and disappeared completely 8 mo nths later, in which regression may be associated with evidence of numerous CD8 cell infiltration in the second biopsy tissues. No recurrence was obse rved during the following 6 month follow up.