Cell bodies of neurons at risk of death in Alzheimer disease have increased
lipid peroxidation, nitration, free carbonyls, and nucleic acid oxidation.
These oxidative changes are uniform among neurons and are seen whether or
not the neurons display neurofibrillary tangles and, in fact, are actually
reduced in the latter case. In consideration of this localization of damage
, in this review, we provide a summary of recent work demonstrating some ke
y abnormalities that may initiate and promote neuronal oxidatave damage. (C
) 2000 ISDN. Published by Elsevier Science Ltd. All rights reserved.