Oxidative damage in Alzheimer's disease: the metabolic dimension

Citation
G. Perry et al., Oxidative damage in Alzheimer's disease: the metabolic dimension, INT J DEV N, 18(4-5), 2000, pp. 417-421
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
ISSN journal
0736-5748 → ACNP
Volume
18
Issue
4-5
Year of publication
2000
Pages
417 - 421
Database
ISI
SICI code
0736-5748(200007/08)18:4-5<417:ODIADT>2.0.ZU;2-9
Abstract
Cell bodies of neurons at risk of death in Alzheimer disease have increased lipid peroxidation, nitration, free carbonyls, and nucleic acid oxidation. These oxidative changes are uniform among neurons and are seen whether or not the neurons display neurofibrillary tangles and, in fact, are actually reduced in the latter case. In consideration of this localization of damage , in this review, we provide a summary of recent work demonstrating some ke y abnormalities that may initiate and promote neuronal oxidatave damage. (C ) 2000 ISDN. Published by Elsevier Science Ltd. All rights reserved.