Identification of a novel HLA-B46 allele, B*4602, in Japanese

Citation
T. Akesaka et al., Identification of a novel HLA-B46 allele, B*4602, in Japanese, TISSUE ANTI, 55(5), 2000, pp. 460-462
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
0001-2815 → ACNP
Volume
55
Issue
5
Year of publication
2000
Pages
460 - 462
Database
ISI
SICI code
0001-2815(200005)55:5<460:IOANHA>2.0.ZU;2-J
Abstract
The B*4602 was identified in a healthy Japanese donor. The B46 variant anti gen differed serologically from B46. The nucleotide sequence of B*4602 diff ered from that of B*4601 by a single base (from A to G) at position 293 in exon 2. The substitution changed the amino acid Asp at position 74 to Gly. The gene frequency of B*4602 in the Japanese population is extremely low, T he presumed haplotype of B*4602 was HLA-A2-Cwl-B*4602-DRB1*09. This is the first report of polymorphism of the B46 antigen.