A new steroidal saponin from the leaves of Agave americana

Citation
A. Yokosuka et al., A new steroidal saponin from the leaves of Agave americana, PLANTA MED, 66(4), 2000, pp. 393-396
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
0032-0943 → ACNP
Volume
66
Issue
4
Year of publication
2000
Pages
393 - 396
Database
ISI
SICI code
0032-0943(200005)66:4<393:ANSSFT>2.0.ZU;2-V
Abstract
A new bisdesmosidic spirostanol saponin, along with three known saponins, w ere isolated from Agave americana (Agavaceae). The structure of the new sap onin was elucidated as (25R)-3 beta,6 alpha-dihydroxy-5 alpha-spirostan-12- one 3,6-di-O-beta-D-glucopyranoside. Among the isolated saponins, hecogenin tetraglycoside showed cytotoxic activity against HL-60 human promyelocytic leukemia cells with an IC50 value of 4.3 mu g/ml.