Atypical hyperplasia of choledocho-pancreatic duct epithelium in an OtsukaLong Evans Tokushima Fatty strain of rats

Citation
M. Kondo et al., Atypical hyperplasia of choledocho-pancreatic duct epithelium in an OtsukaLong Evans Tokushima Fatty strain of rats, PATHOL INT, 50(2), 2000, pp. 126-135
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
PATHOLOGY INTERNATIONAL
ISSN journal
1320-5463 → ACNP
Volume
50
Issue
2
Year of publication
2000
Pages
126 - 135
Database
ISI
SICI code
1320-5463(200002)50:2<126:AHOCDE>2.0.ZU;2-L
Abstract
Epithelial papillary hyperplasia of choledocho-pancreatic duct, associated with cellular atypism, was observed in Otsuka Long Evans Tokushima Fatty (O LETF) rats, a strain originally established as an animal model for non-insu lin-dependent diabetes mellitus (NIDDM). To investigate the potential feasi bility of OLETF rats as an animal model for pancreatic ductal carcinoma, we examined the pathological characteristics of ductal lesions in OLETF rats aged from 5 to 50 weeks. Hyperplastic lesions in OLETF rats became apparent after 10 weeks of age and increased in severity and frequency of atypical changes in hyperplastic epithelium appearing after 20 weeks. We compared du ctal lesions from OLETF rats with those from age-matched Long Evans Tokushi ma Otsuka (LETO) rats, which share a similar genetic background with OLETF rats but do not develop NIDDM, While LETO rats also display a tendency towa rd ductal hyperplasia, lesions from OLETF rats were more numerous and large r in size than those from age-matched LETO rats. In addition, lesions from OLETF rats contained a significantly higher number of proliferating cell nu clear antigen-positive cells than those from LETO rats. Finally lesions in OLETF rats were accompanied by inflammation, and the observed morphological alteration of lesions correlated well with the grade of inflammation.