Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension

Citation
Mc. Armas-padilla et al., Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension, J HUM HYPER, 14, 2000, pp. S91-S95
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF HUMAN HYPERTENSION
ISSN journal
0950-9240 → ACNP
Volume
14
Year of publication
2000
Supplement
1
Pages
S91 - S95
Database
ISI
SICI code
0950-9240(200004)14:<S91:EOLANG>2.0.ZU;2-V
Abstract
With the aim of evaluating the effects on blood pressure, platelet function and insulin sensitivity of the dihydropiridines lacidipine and nifedipine GITS, a parallel double-blind study was carried out in a group of 20 patien ts with mild to moderate essential hypertension, They received a placebo fo r 4 weeks; then were divided at random into two groups of 10 patients each. Nifedipine GITS, 30 mg and lacidipine, 4 mg, were given during 16 weeks of active treatment. Blood pressure and heart rate were measured at the clini c in supine, sitting and standing positions, 24 +/- 1 h after the last dose , After the placebo and active phases were carried out, a platelet aggregat ion test was performed to determine platelet malondialdehyde production and a tolerance to 100 g of glucose by measuring glucaemia and plasma insulin. Both drugs reduced systolic and diastolic blood pressure at the same level , however there were observable differences in the rate of reduction. The n ifedipine GITS reduced supine systolic blood pressure by 25 mm Hg in the fi rst week, while the lacidipine did so by 11 mm Hg, At the end of the study period nifedipine reduced supine systolic blood pressure by 28 mm Hg and la cidipine by 20 mm Hg. Heart rate was increased slightly but significantly i n the nifedipine GITS group only in the standing position. Both drugs reduc ed platelet aggregation ex vivo only marginally but they modified the malon dialdehyde production, indicating an action on the arachidonic acid metabol ic pathway.