Angiotensin II receptor antagonists in arterial hypertension

Citation
R. Hernandez-hernandez et al., Angiotensin II receptor antagonists in arterial hypertension, J HUM HYPER, 14, 2000, pp. S69-S72
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF HUMAN HYPERTENSION
ISSN journal
0950-9240 → ACNP
Volume
14
Year of publication
2000
Supplement
1
Pages
S69 - S72
Database
ISI
SICI code
0950-9240(200004)14:<S69:AIRAIA>2.0.ZU;2-Y
Abstract
Angiotensin II receptor antagonists (AT-1) represent a new group of orally active antihypertensive agents. Activation on AT-1 receptor leads to vasoco nstriction, stimulation of the release of catecholamines and antidiuretic h ormone with production of thirst, and promote growth of vascular and cardia c muscle; these effects are blocked by AT-1 antagonist agents. The first ch emically useful, orally active AT-1 receptor antagonist was losartan, follo wed by other agents currently in clinical use, such as: valsartan, eprosart an, irbesartan, telmisaptan, candesartan, and many others under investigati on. AT-1 receptor antagonists are effective in reducing high blood pressure in hypertensive patients. Monotherapy in mild to moderate hypertension con trols blood pressure in 40 to 50% of these patients; when a low dose of a t hiazide diuretic is added, 60 to 70% of patients are controlled. The effica cy is similar to angiotensin-converting enzyme inhibitors, diuretics, calci um antagonists and beta-blocking agents. Tolerability has been reported to be very good. AT-I receptor antagonists would be a drug of choice in otherw ise well-controlled hypertensive patients treated with angiotensin-converti ng enzyme inhibitors who developed cough or angioedema. The final position in the antihypertensive therapy in this special population and other clinic al situations, such as left ventricular hypertrophy, heart failure, diabete s mellitus and renal disease, has to be determined in large prospective cli nical trials, some of which are now being conducted.