Diabetes and hypertension physiopathology and therapeutics

Citation
F. Contreras et al., Diabetes and hypertension physiopathology and therapeutics, J HUM HYPER, 14, 2000, pp. S26-S31
Citations number
35
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF HUMAN HYPERTENSION
ISSN journal
0950-9240 → ACNP
Volume
14
Year of publication
2000
Supplement
1
Pages
S26 - S31
Database
ISI
SICI code
0950-9240(200004)14:<S26:DAHPAT>2.0.ZU;2-N
Abstract
Diabetes mellitus by itself, is a frequent and increasing public health pro blem. The prevalence in most Western countries varies between 2 to 5% and i t is rapidly increasing in Asiatic countries due to changes in dietary habi ts during the last years. The association between diabetes mellitus and hyp ertension has been described in 60 to 65% of diabetics. In hypertension we find insulin resistance mainly in skeletal muscle involving the conversion of glucose to glycogen independently of blood flow. The degree of resistanc e is related to the severity of hypertension and varies between races. Stat es of hyperinsulinaemia and insulin-resistance have been postulated as caus es and/or consequences of hypertension. Regardless of the type of diabetes, hypertension is two to three times more common among diabetics compared wi th non-diabetics. In this paper we propose to review the essential physiopa thological mechanisms involved in this association that causes high morbidi ty and mortality rates and increases disability among the population involv ed.