Successful rescue of severe recurrent hepatitis C with interferon and ribavirin in a liver transplant patient

Citation
S. Muramatsu et al., Successful rescue of severe recurrent hepatitis C with interferon and ribavirin in a liver transplant patient, TRANSPLANT, 69(9), 2000, pp. 1956-1958
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TRANSPLANTATION
ISSN journal
0041-1337 → ACNP
Volume
69
Issue
9
Year of publication
2000
Pages
1956 - 1958
Database
ISI
SICI code
0041-1337(20000515)69:9<1956:SROSRH>2.0.ZU;2-G
Abstract
Background Rapid graft dysfunction caused by hepatitis C virus (HCV) reinfe ction, although uncommon, is a disastrous complication in liver transplant patients, Finding an effective therapy for this subgroup of patients with s evere recurrent HCV is a priority. Method. We describe a successful rescue of a 46-year-old man with recurrent hepatitis C (HCV genotype 1b) using long-term interferon (IFN) and ribavir in. The patient had a very aggressive type of posttransplantation HCV infec tion, as judged by biochemical and histologic findings. Results. Despite high pretreatment values of serum alanine aminotransferase (ALT; peak value of 901 IU/L), and HCV-RNA (2.3 x 10(6) copies/ml), the co mbination therapy with IFN and ribavirin produced a rapid normalization of the serum ALT values, accompanied by the clearance of serum HCV-RNA. Althou gh HCV-RNA reappeared in the serum at 3 months, the patient had continued A LT normalization and histological improvement with follow-up of over 26 mon ths to date after the initiation of the combination therapy. Conclusion. This observation suggests that IFN in combination with ribaviri n may offer an effective therapeutic option for liver transplant patients w ith severe recurrent hepatitis C.