Hippocampal volume and everyday memory in children of very low birth weight

Citation
Eb. Isaacs et al., Hippocampal volume and everyday memory in children of very low birth weight, PEDIAT RES, 47(6), 2000, pp. 713-720
Citations number
55
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
PEDIATRIC RESEARCH
ISSN journal
0031-3998 → ACNP
Volume
47
Issue
6
Year of publication
2000
Pages
713 - 720
Database
ISI
SICI code
0031-3998(200006)47:6<713:HVAEMI>2.0.ZU;2-6
Abstract
Children born preterm and of very low birth weight have an increased incide nce of learning difficulties, but little is known about the specific nature of their cognitive deficits and the underlying neuropathology. We hypothes ized that their vulnerability to hypoxic, metabolic, and nutritional insult s would lead to reduced hippocampal volumes and to deficits in memory becau se of the role of the hippocampus in this domain of cognition. Neuropsychol ogical and magnetic resonance imaging methods were used to investigate this hypothesis in adolescents born preterm (less than or equal to 30 wk gestat ion, n = 11) or full-term (n = 8). The preterm group had significantly smal ler hippocampal volumes bilaterally, despite equivalent head size, acid sho wed specific deficits in certain aspects of everyday memory, both on object ive testing and as indicated by parental questionnaires. The preterm group also had a specific deficit in numeracy. The reduced hippocampal volumes an d deficits in everyday memory have previously been unrecognized, but their prevalence in a group of neurologically normal children is striking.