RBE-LET relationships in mutagenesis by ionizing radiation

Citation
H. Nikjoo et al., RBE-LET relationships in mutagenesis by ionizing radiation, J RADIAT R, 40, 1999, pp. 85-105
Citations number
55
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
JOURNAL OF RADIATION RESEARCH
ISSN journal
0449-3060 → ACNP
Volume
40
Year of publication
1999
Supplement
S
Pages
85 - 105
Database
ISI
SICI code
0449-3060(199912)40:<85:RRIMBI>2.0.ZU;2-V
Abstract
The paper considers the relationship between the quality of radiation and b iological lesions produced by ionizing radiation. The paper provides a brie f review of the modelling of induction of strand breakage, chromosome aberr ation, revertant mutation in bacteria and Drosophila melanogaster. Experime ntal data are presented for the relative biological effectiveness of helium ions and alpha-particles for mutation induction and genome lethality in Es cherichia coli. The paper examines the relationship between the mutational events and LET. The RBE-LET values for T4 phage, E. coli WP2 and mwh (multi ple wing hair) show dependency on LET while the w(i) (white-ivory) allele m utants show no dependency.