D-Va category phenotype and genotype in Japanese families

Citation
Tj. Legler et al., D-Va category phenotype and genotype in Japanese families, VOX SANGUIN, 78(3), 2000, pp. 194-197
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
VOX SANGUINIS
ISSN journal
0042-9007 → ACNP
Volume
78
Issue
3
Year of publication
2000
Pages
194 - 197
Database
ISI
SICI code
0042-9007(2000)78:3<194:DCPAGI>2.0.ZU;2-3
Abstract
Background and Objectives: The genetic background of the D-Va category phen otype has been described in two Caucasian individuals. We were interested i n the RHD sequence of 7 Japanese D-Va individuals and their families. Mater ials and Methods: With SSP-PCR we tested exons 4, 5 and 7 of the RHD gene a nd used restriction enzymes for testing nucelotide associated with the D-Va phenotype. Results: A single RHD G667 C697 allele was present in 5 individ uals with D-Va category phenotype, and in 2 individuals we found a D-CE-D h ybrid gene (exon 5 had been replaced). The (DCe)-Ce-Va gene complex was fou nd in all families, Conclusion: The changes of the RHD gene described in Eu ropean D-Va individuals were also observed in Japanese families. Copyright (C) 1999 S. Karger AG, Basel.