Encouraging results in the treatment of haemorrhagic cystitis with estrogen - report of 10 cases and review of the literature

Citation
R. Ordemann et al., Encouraging results in the treatment of haemorrhagic cystitis with estrogen - report of 10 cases and review of the literature, BONE MAR TR, 25(9), 2000, pp. 981-985
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Journal title
BONE MARROW TRANSPLANTATION
ISSN journal
0268-3369 → ACNP
Volume
25
Issue
9
Year of publication
2000
Pages
981 - 985
Database
ISI
SICI code
0268-3369(200005)25:9<981:ERITTO>2.0.ZU;2-P
Abstract
Haemorrhagic cystitis (HC) after allogeneic haematopoietic stem cell transp lantation (HSCT) or high-dose cyclophosphamide (CP) chemotherapy is a sever e side-effect and can cause significant morbidity and mortality. In this re port, we describe the clinical courses of 10 patients with HC and review th e literature. The patients were treated with oral conjugated estrogen in an attempt to improve severe haemorrhagic cystitis. In seven patients positiv e effects were seen, haematuria resolved in all, but residual symptoms of d ysuria remained for longer periods. In one patient application of estrogen was interrupted because of hepatotoxicity. Two patients failed all treatmen t modalities including oral estrogen because of terminal illness. We conclu de that in the management of HC the administration of oral conjugated estro gen should be considered.