R. Ordemann et al., Encouraging results in the treatment of haemorrhagic cystitis with estrogen - report of 10 cases and review of the literature, BONE MAR TR, 25(9), 2000, pp. 981-985
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Haemorrhagic cystitis (HC) after allogeneic haematopoietic stem cell transp
lantation (HSCT) or high-dose cyclophosphamide (CP) chemotherapy is a sever
e side-effect and can cause significant morbidity and mortality. In this re
port, we describe the clinical courses of 10 patients with HC and review th
e literature. The patients were treated with oral conjugated estrogen in an
attempt to improve severe haemorrhagic cystitis. In seven patients positiv
e effects were seen, haematuria resolved in all, but residual symptoms of d
ysuria remained for longer periods. In one patient application of estrogen
was interrupted because of hepatotoxicity. Two patients failed all treatmen
t modalities including oral estrogen because of terminal illness. We conclu
de that in the management of HC the administration of oral conjugated estro
gen should be considered.