Locomotor and learning deficits in adult rats exposed to monosodium-L-glutamate during early life

Citation
Mm. Ali et al., Locomotor and learning deficits in adult rats exposed to monosodium-L-glutamate during early life, NEUROSCI L, 284(1-2), 2000, pp. 57-60
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
0304-3940 → ACNP
Volume
284
Issue
1-2
Year of publication
2000
Pages
57 - 60
Database
ISI
SICI code
0304-3940(20000421)284:1-2<57:LALDIA>2.0.ZU;2-Z
Abstract
Neonatal administration of neurotoxic doses of monosodium-L-glutamate (MSG) to rats causes neuronal necrosis of the hypothalamus along with behavioral abnormalities. In the present study the behavioral effects in rats treated with subneurotoxic doses of MSG (2 mg/g, p.o.,for 10 days) at the weaned s tage were investigated at day 90 post-dosing. The MSG-treated rats did not show significant changes in any of the components of spontaneous locomotor activity but, after apomorphine challenge, marked decreases in the distance travelled, ambulatory and stereotypic times, and the number of stereotypic movements with an increase in the resting time were observed. Significant decrease in the active avoidance learning performance was observed in the M SG-treated rats in the learning (acquisition) phase without any changes in the extinction and relearning phases. The results indicate that exposure to MSG in early life in rats could lead to subtle behavioral aberrations in l ate adulthood. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.