Survival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion

Citation
H. Chai et al., Survival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion, NEUROREPORT, 11(6), 2000, pp. 1249-1252
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
11
Issue
6
Year of publication
2000
Pages
1249 - 1252
Database
ISI
SICI code
0959-4965(20000427)11:6<1249:SAROMI>2.0.ZU;2-7
Abstract
The present study examines whether reimplantation of the ventral root could prevent motoneuron death after root avulsion. in the control animals about 65% or 39% of motoneurons survived at 3 or 6 weeks post-injury respectivel y. More than 60% of them expressed nitric oxide synthase (NOS). In contrast , in animals with ventral root reimplantation, nearly 90% or 80% of motoneu rons survived at 3 or 6 weeks post-injury respectively. Expression of NOS d ue to root avulsion was significantly inhibited in these experimental anima ls. More interestingly, about 80% of the surviving motoneurons were found t o regenerate their axons into the reimplanted ventral root, and all of thes e regenerating motoneurons were NOS negative. Results of the present study show that reimplantation of avulsed ventral root can greatly enhance motone uron survival and the surviving motoneurons can regrow their axons into the original ventral root. NeuroReport 11:1249-1252 (C) 2000 Lippincott Willia ms & Wilkins.