Zinc deficiency impairs immune responses against parasitic nematode infections at intestinal and systemic sites

Citation
Me. Scott et Kg. Koski, Zinc deficiency impairs immune responses against parasitic nematode infections at intestinal and systemic sites, J NUTR, 130(5), 2000, pp. 1412S-1420S
Citations number
59
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Food Science/Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF NUTRITION
ISSN journal
0022-3166 → ACNP
Volume
130
Issue
5
Year of publication
2000
Supplement
S
Pages
1412S - 1420S
Database
ISI
SICI code
0022-3166(200005)130:5<1412S:ZDIIRA>2.0.ZU;2-B
Abstract
Research on the complex interactions among host nutritional status, parasit ic infection and immune responsiveness has focused on the detrimental conse quences of parasitic infections on host nutritional status and on mechanism s by which malnutrition impairs immunocompetence, Curiously, relatively few studies have examined the effects of malnutrition on the immune response i n the parasite-infected host, and even fewer have considered the events occ urring at the intestinal level, where absorption of nutrients occurs, intes tinal parasites reside, and the gastrointestinal-associated lymphoid tissue s play a role in directing both the local and the more systemic immune resp onses, Our work using a zinc-deficient nematode-infected mouse model reveal s that parasites are better able to survive in the zinc-deficient hosts tha n in well-nourished hosts; that the production of interleukin-4 in the sple en of zinc-deficient mice is depressed, leading to depressed levels of IgE, IgG(1) and eosinophils; and that the function of T cells and antigen-prese nting cells is impaired by zinc deficiency as well as by energy restriction , Given the paramount role of the gastrointestinal-associated lymphoid tiss ues in inducing and regulating immune responses to intestinal parasites and in orchestrating responses in the spleen and peripheral circulation, we co nclude that zinc deficiency (in association with energy restriction) exerts profound effects on the gut mucosal immune system, leading to changes in s ystemically disseminated immune responses and, importantly, to prolonged pa rasite survival.