HLA patterns in patients with nasal polyposis

Citation
W. Luxenberger et al., HLA patterns in patients with nasal polyposis, EUR ARCH OT, 257(3), 2000, pp. 137-139
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Otolaryngology
Journal title
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
ISSN journal
0937-4477 → ACNP
Volume
257
Issue
3
Year of publication
2000
Pages
137 - 139
Database
ISI
SICI code
0937-4477(200003)257:3<137:HPIPWN>2.0.ZU;2-T
Abstract
The etiology of nasal polyposis is still unknown, although risk factors inc lude Aspirin intolerance, asthma, cystic fibrosis and primary ciliary dyski nesia. We studied frequencies of HLA A, B, DR and DQ in patients with nasal polyposis in order to determine a possible genetic component in the multif actorial pathogenesis of nasal polyps. Previous work has suggested an assoc iation of HLA-A1B8 with nasal polyposis and Aspirin intolerance. We investi gated 89 patients with nasal polyposis, 11 of whom had Aspirin-intolerance, 19 asthma and 22 allergies to inhalation allergens. HLA patterns of these patients were compared to the ones of 1,070 healthy controls. No significan t association of HLA-A1B8 was found with nasal polyps in the Aspirin-sensit ive subgroup of our patients, but a significant association was seen with H LA-A74 and nasal polyposis.