Gastrin producing ovarian tumor is a rare cause of the Zollinger-Ellison sy
ndrome. We report the case of an ovarian carcinoma showing increased plasma
gastrin concentration. A 60-yr-old woman presented with epigastric pain an
d diarrhea. Physical examination showed a large mass in the lower abdomen.
Computed tomography revealed a large multilocular ovarian cyst. Upper gastr
ointestinal endoscopy examination showed multiple ulcerations of the stomac
h and duodenum. The plasma gastrin level was 1500 pg/ml. No tumors were fou
nd in the pancreas and duodenum, and salpingo-oophorectomy was performed. H
istologic examination revealed a mucinous tumor of borderline malignant pot
ential. Immunoperoxidase studies for gastrin showed many gastrin-producing
cells within the epithelium of the tumor. There have been 11 cases (includi
ng our patient) of gastrin-producing ovarian tumor reported in the literatu
re. We review here the relevant literature. Although ovarian gastrinoma is
extremely rare, it should be considered as a possible cause of the Zollinge
r-Ellison syndrome in women. (C) 2000 by Am. Coll. of Gastroenterology.