Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: Report of a case and review of the literature

Citation
K. Hirasawa et al., Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: Report of a case and review of the literature, AM J GASTRO, 95(5), 2000, pp. 1348-1351
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
AMERICAN JOURNAL OF GASTROENTEROLOGY
ISSN journal
0002-9270 → ACNP
Volume
95
Issue
5
Year of publication
2000
Pages
1348 - 1351
Database
ISI
SICI code
0002-9270(200005)95:5<1348:OMCAAC>2.0.ZU;2-7
Abstract
Gastrin producing ovarian tumor is a rare cause of the Zollinger-Ellison sy ndrome. We report the case of an ovarian carcinoma showing increased plasma gastrin concentration. A 60-yr-old woman presented with epigastric pain an d diarrhea. Physical examination showed a large mass in the lower abdomen. Computed tomography revealed a large multilocular ovarian cyst. Upper gastr ointestinal endoscopy examination showed multiple ulcerations of the stomac h and duodenum. The plasma gastrin level was 1500 pg/ml. No tumors were fou nd in the pancreas and duodenum, and salpingo-oophorectomy was performed. H istologic examination revealed a mucinous tumor of borderline malignant pot ential. Immunoperoxidase studies for gastrin showed many gastrin-producing cells within the epithelium of the tumor. There have been 11 cases (includi ng our patient) of gastrin-producing ovarian tumor reported in the literatu re. We review here the relevant literature. Although ovarian gastrinoma is extremely rare, it should be considered as a possible cause of the Zollinge r-Ellison syndrome in women. (C) 2000 by Am. Coll. of Gastroenterology.