Increased hemostatic molecular markers in patients undergoing anticoagulant therapy

Citation
H. Wada et al., Increased hemostatic molecular markers in patients undergoing anticoagulant therapy, SEM THROMB, 26(1), 2000, pp. 113-118
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
SEMINARS IN THROMBOSIS AND HEMOSTASIS
ISSN journal
0094-6176 → ACNP
Volume
26
Issue
1
Year of publication
2000
Pages
113 - 118
Database
ISI
SICI code
0094-6176(2000)26:1<113:IHMMIP>2.0.ZU;2-M
Abstract
We evaluated several molecular markers of hemostasis in 92 patients with hy percoagulable states treated with anticoagulant therapy. In all patients, t he average values of the international normalized ratio (INR) were 1.70 +/- 0.50; this increase in INR was not, however, significant in patients under thrombotest (TT) monitoring. There were no thrombotic or severe bleeding c omplications in these patients during a period of 27 months. Plasma levels of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex ( PPIC), D-dimer, and soluble fibrin monomer (sFM) were slightly increased, s uggesting that anticoagulant therapy was not completely effective in our Ja panese patients based on the values of the TT The INR was negatively correl ated with TT, protein C, and protein S and particularly with TT between 10 and 80%. The range of TT was not correlated with the plasma level of TAT, P PIC, D-dimer, or sFM, but the range of INR was correlated with the plasma l evel of TAT, D-dimer, and sFM. The percentage of TAT, D-dimer, and sFM with in normal range was significantly lower in patients with high INR. These fi ndings show that INR is better than TT for the monitoring of warfarin thera py and that the therapeutic values of INR during the anticoagulant therapy should be > 1.7 in Japanese patients.