Diagnosis of disseminated intravascular coagulation by hemostatic molecular markers

Citation
H. Wada et al., Diagnosis of disseminated intravascular coagulation by hemostatic molecular markers, SEM THROMB, 26(1), 2000, pp. 17-21
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
SEMINARS IN THROMBOSIS AND HEMOSTASIS
ISSN journal
0094-6176 → ACNP
Volume
26
Issue
1
Year of publication
2000
Pages
17 - 21
Database
ISI
SICI code
0094-6176(2000)26:1<17:DODICB>2.0.ZU;2-L
Abstract
In the present study, the positive rate of thrombin-antithrombin complex (T AT), plasmin-plasmin inhibitor complex (PPIC), soluble fibrin monomer (sFM) , and D-dimer for the diagnosis of disseminated intravascular coagulation ( DIG) was evaluated. The study comprised 307 patients with DIG, 123 with pre -DIG, and 121 with non-DIG. Plasma levels of TAT, PPIC, sFM, and D-dimer we re significantly higher in DIG and pre-DIG patients than in non-DIG patient s. In DIG patients, the positive rate of sFM was high and that of D-dimer w as low; the positive rate of PPIC was higher in patients with hematopoietic malignancy than in those without this disease. In pre-DIG patients, the po sitive rate of all markers was low (<0.16), and the positive rate of PPIC w as relatively high. In non-DIG patients, the positive rate of all hemostati c markers was low (<0.16), that of sFM being the lowest. Scoring the positi ve rate of TAT, PPIC, and sFM disclosed the following results: 72% of DIG p atients had three or more points, 17.6% of pre-DIG patients had three or mo re points, and almost all (96.6%) non-DIG patients had two or less points. Scoring the positive rate of TAT, PPIC, and D-dimer disclosed the following results: 52.9% of DIG patients and 27.4% of pre-DIG patients had three or more points and almost all (96.7%) non-DIG patients had 2 or less points. T hese data suggest that the combination of TAT, PPIC, and sFM is useful for making the diagnosis of DIC.