Induction of choline acetyltransferase activity in cholinergic neurons by stolonidiol: Structure-activity relationship

Citation
T. Yabe et al., Induction of choline acetyltransferase activity in cholinergic neurons by stolonidiol: Structure-activity relationship, J NAT PROD, 63(4), 2000, pp. 433-435
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
63
Issue
4
Year of publication
2000
Pages
433 - 435
Database
ISI
SICI code
0163-3864(200004)63:4<433:IOCAAI>2.0.ZU;2-G
Abstract
The effect of stolonidiol (1), a bioactive marine diterpenoid from the Japa nese soft coral Clavularia sp., on choline acetyltransferase (ChAT) activit y was examined using cultured cholinergic neurons. Stolonidiol (1) showed p otent ChAT inducible activity in primary cultured basal forebrain cells and clonal septal SN49 cells, suggesting that it may act as a potent neurotrop hic factor-like agent on the cholinergic nervous system. Further expansion of the structure-activity relationship to include stolonidiol (1) and its d erivatives demonstrated that the exo-methylene group and the epoxide group are essential for ChAT-inducing activity. Stolonidiol (1) showed the highes t activity among the test samples.