Comparison of respiratory indices in predicting response to high frequencyoscillatory ventilation in very low birth weight infants with respiratory distress syndrome

Citation
Sy. Ko et al., Comparison of respiratory indices in predicting response to high frequencyoscillatory ventilation in very low birth weight infants with respiratory distress syndrome, J KOR MED S, 15(2), 2000, pp. 153-158
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN journal
1011-8934 → ACNP
Volume
15
Issue
2
Year of publication
2000
Pages
153 - 158
Database
ISI
SICI code
1011-8934(200004)15:2<153:CORIIP>2.0.ZU;2-9
Abstract
To evaluate the predictive values of oxygenation index (OI), arterial-alveo lar oxygen tension ratio (a/APO)(2), and alveolar-arterial oxygen gradient ((A-a)DO2) for early recognition of responsiveness to high frequency oscill atory ventilation (HFOV) in very low birth weight infants with respiratory distress syndrome (RDS), 23 infants who received HFOV treatment for severe RDS after failing to be improved with conventional mechanical ventilation f rom July 1995 to February 1998 were included, Twelve infants survived with HFOV (Responder group), while 11 infants could not maintain oxygenation wit h HFOV and died (Non-responder group). Clinical record (of each patient) we re retrospectively reviewed and compared with the respiratory indices. Mean (A-a)DO2 was significantly lower in the responder group than in the non-re sponder group at 2 hr after HFOV (p=0.024), and the difference was more rem arkable at 6 hr (p=0.005). Death in the patient with (A-a)DO2 over 350 at 2 hr after HFOV therapy was 100% in sensitivity and 80% in specificity. The earliest significant difference of mean a/APO(2) between two groups was not ed at 6 hr after HFOV treatment (p=0.019). OI showed no significant differe nces between two groups. In summary, (A-a)DO2 was the most effective and se nsitive respiratory index for predicting the responsiveness to HFOV in infa nts with severe RDS providing clue as early as 2 hr.