Functional dissection of BCR signaling pathways

Authors
Citation
T. Kurosaki, Functional dissection of BCR signaling pathways, CURR OP IM, 12(3), 2000, pp. 276-281
Citations number
54
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
0952-7915 → ACNP
Volume
12
Issue
3
Year of publication
2000
Pages
276 - 281
Database
ISI
SICI code
0952-7915(200006)12:3<276:FDOBSP>2.0.ZU;2-E
Abstract
Signal transduction by the BCR is critical for progression through developm ental checkpoints as well as for immune responses. Recent results obtained in mice deficient either in an adaptor molecule, BLNK (alternatively named SLP-65 or BASH), or in phosphatidylinositol 3-kinase have revealed similar - though not identical - phenotypes to those of Btk(-/-) mice, suggesting a functional link between BLNK, Btk and phosphatidylinositol 3-kinase.