Cardiac sympathetic activity in the asymmetrically hypertrophied septum inpatients with hypertension or hypertrophic cardiomyopathy

Citation
M. Shimizu et al., Cardiac sympathetic activity in the asymmetrically hypertrophied septum inpatients with hypertension or hypertrophic cardiomyopathy, CLIN CARD, 23(5), 2000, pp. 365-370
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
CLINICAL CARDIOLOGY
ISSN journal
0160-9289 → ACNP
Volume
23
Issue
5
Year of publication
2000
Pages
365 - 370
Database
ISI
SICI code
0160-9289(200005)23:5<365:CSAITA>2.0.ZU;2-E
Abstract
Background: In patients with essential hypertension (I-IT), proportional (s ymmetric) left ventricular hypertrophy (LVH) is common. In contrast, hypert rophic cardiomyopathy (HCM) is characterized by dispropomonal LVH and, in p articular, asymmetric septal hypertrophy (ASH); however, some hypertensive patients also develop ASH. It has not been determined whether such cases re present a distinct type of hypertensive LVH or HCM combined with hypertensi on. Hypothesis: The study was undertaken to evaluate sympathetic activity in th e interventricular septum in patients with HT and ASH or in patients with H CM. Methods: The patients were evaluated by I-123 metaiodobenzylguanidine (MIBG ) and thallium-201 (Tl-201) single-photon emission computed tomography (SPE CT), respectively. They were divided into three groups: patients with essen tial HT and symmetric septal hypertrophy (Group A), patients with HT and AS H (Group B), and patients with HCM and ASH (Group C). Results: Compared with the lateral wall, early uptake of MIBG in the septum was significantly higher in Group B than in Group A, but not significantly different between Groups A and C. Compared with the lateral wall, early up take of Tl-201 in the septum did not differ among the three groups. No sign ificant difference in the MIBG clearance in the lateral wall was seen among the three groups. By contrast, MIBG clearances in the septum and apex were significantly greater in Group C than in Groups A and B. There was an inve rse correlation be tween systolic thickening and MIBG clearance in the sept um. Conclusion: These findings suggest that sympathetic activity in the septum differs between patients with HT and ASH and patients with HCM.