Experimental prostate carcinogenesis - rodent models

Citation
T. Shirai et al., Experimental prostate carcinogenesis - rodent models, MUT RES-R M, 462(2-3), 2000, pp. 219-226
Citations number
52
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
ISSN journal
1383-5742 → ACNP
Volume
462
Issue
2-3
Year of publication
2000
Pages
219 - 226
Database
ISI
SICI code
1383-5742(200004)462:2-3<219:EPC-RM>2.0.ZU;2-G
Abstract
A number of rodent models of prostate carcinoma development have been estab lished to study mechanisms and modifying potential. All except for transgen ic mouse models need long experimental periods for generation of a high yie ld of cancers. Spontaneous prostate tumor models, while not practical in te rms of time and tumor incidences, allow the natural course of multistep neo plasia to be followed without a need for chemical exposure. Carcinogens, es pecially in combination with testosterone, can induce prostate carcinomas i n rats, but none are prostate-specific, so that tumor development in other organs is a complicating factor. Induction of invasive prostate carcinomas in the rat frequently requires long-term administration of a pharmacologica l dose of testosterone with or without application of a chemical carcinogen . While there are several transgenic mouse models, each also has strong and weak points, and it is therefore necessary to select the best model for th e purpose of any experimental study. (C) 2000 Elsevier Science B.V. All rig hts reserved.