Orthogonal acceleration time-of-flight mass spectrometry

Citation
M. Guilhaus et al., Orthogonal acceleration time-of-flight mass spectrometry, MASS SPECTR, 19(2), 2000, pp. 65-107
Citations number
124
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
MASS SPECTROMETRY REVIEWS
ISSN journal
0277-7037 → ACNP
Volume
19
Issue
2
Year of publication
2000
Pages
65 - 107
Database
ISI
SICI code
0277-7037(200003/04)19:2<65:OATMS>2.0.ZU;2-7
Abstract
The principles and applications of time-of-flight mass spectrometry involvi ng instruments with independent (orthogonal) axes for ion generation and ma ss analysis are reviewed. This approach, generally referred to as orthogona l acceleration time-of-flight mass spectrometry, has proved particularly ad vantageous for the combination of continuous ionization sources with time-o f-flight mass spectrometry. The history of the technique is briefly discuss ed along with the instrumental principles pertaining to all the stages of t he instrumentation from ion source to detector. The applications of commerc ial and customized instruments are discussed for several ionization methods including electrospray, matrix assisted laser desorption/ionization, elect ron ionization, and plasma ionization. (C) 2000 John Wiley & Sons, Inc.