Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery

Citation
Y. Kotake et al., Additional droperidol, not butorphanol, augments epidural fentanyl analgesia following anorectal surgery, J CLIN ANES, 12(1), 2000, pp. 9-13
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care
Journal title
JOURNAL OF CLINICAL ANESTHESIA
ISSN journal
0952-8180 → ACNP
Volume
12
Issue
1
Year of publication
2000
Pages
9 - 13
Database
ISI
SICI code
0952-8180(200002)12:1<9:ADNBAE>2.0.ZU;2-K
Abstract
Study Objective: To examine the effects of additional droperidol or butorph anol to epidural fentanyl infusion on postsurgical analgesia. Design: Prospective, randomized, single blinded clinical study. Setting: University-affiliated medical center. Patients: 60 ASA physical status I and II patients undergoing anorectal sur gery by one surgeon. Interventions: Patients were randomly allocated to the following groups acc ording to the medication that was continuously administered into the epidur al space: 1) Group C (n = 20) received 0.4 mg fentanyl in 40 ml of 0.125% b upivacaine; 2) Group D (n = 20) received 2.5 mg droperidol and 0.4 mg fenta nyl in 40 ml of 0.125% bupivacaine; and 3) Group B (n = 20) received 2 mg b utorphanol and 0.4 mg fentanyl in 40 ml of 0.125% bupivacaine over 24 hours postoperatively. Measurements and Main Result: Postsurgical analgesia and the incidence of f entanyl-related complications, such as nausea/vomiting, somnolence, pruritu s, and respiratory depression, were assessed for 24 hours postoperatively. At 16 and 24 hours after surgery, 75% of patients in Group D reported no pa in versus 35% in Group C (p < 0.05). In addition, the overall visual analog ue scale examined at 24 hours was significantly lower in Group D than that in Group C (22 +/- 17 mm vs. 44 +/- 22 mm, respectively; p < 0.05). Simulta neously, the incidence of postoperative nausea/vomiting was lower in Group D compared with Group C (20% vs. 60%; p < 0.05). On the other hand butorpha nol did not modify the analgesic effects or complications of epidural fenta nyl infusion. Conclusion: In this study population, additional droperidol, not butorphano l, improved postsurgical analgesia accompanied by less incidence of nausea/ vomiting during epidural fentanyl administration. (C) 2000 by Elsevier Scie nce Inc.